Publications

2024

• TR(i)P goes on: auxiliary TRP channel subunits? Veit Flockerzi, Bernd Fakler Circulation research 134 (4) : 346-350 10.1161/circresaha.123.323178 View in FreiDok
• Synchronized assembly of the oxidative phosphorylation system controls mitochondrial respiration in yeast Daiana N. Moretti-Horten, Carlotta Peselj, Asli Aras Taskin, Lisa Myketin, Uwe Schulte, Oliver Einsle, Friedel Drepper, Marcin Luzarowski, Friederike Nora Vögtle Developmental cell 59 (8) : 1043-1057.e8 10.1016/j.devcel.2024.02.011 View in FreiDok
• OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage Volodymyr Tsvilovskyy, Roger Ottenheijm, Ulrich Kriebs, Aline Schütz, Kalliope Nina Diakopoulos, Wolfgang Bildl, Norbert Klugbauer, Bernd Fakler, Uwe Schulte, Shmuel Muallem, Marc Freichel Journal of clinical investigation 134 (7) : e169428 10.1172/jci169428 View in FreiDok
• Spine plasticity of dentate gyrus parvalbumin-positive interneurons is regulated by experience Dorthe Kaufhold, Eduardo Maristany de las Casas, María Del Ángel Ocaña-Fernández, Aurore Cazala, Mei Yuan, Akos Kulik, Thibault Cholvin, Stefanie Steup, Jonas-Frederic Sauer, Mark D. Eyre, Claudio Elgueta, Michael Strüber, Marlene Bartos Cell reports 43 (3) : 113806 10.1016/j.celrep.2024.113806 View in FreiDok
• Role of the small protein Mco6 in the mitochondrial sorting and assembly machinery Jon V. Busto, Iniyan Ganesan, Hannah Mathar, Conny Steiert, Eva F. Schneider, Sebastian P. Straub, Lars Ellenrieder, Jiyao Song, Sebastian B. Stiller, Philipp Lübbert, Ritwika Chatterjee, Jana Elsaesser, Laura Melchionda, Christina Schug, Fabian den Brave, Uwe Schulte, Till Klecker, Claudine Kraft, Bernd Fakler, Thomas Becker, Nils Wiedemann Cell reports 43 (3) : 113805 10.1016/j.celrep.2024.113805 View in FreiDok
• Identification of MIMAS, a multifunctional mega-assembly integrating metabolic and respiratory biogenesis factors of mitochondria Patrick Horten, Kuo Song, Joshua Garlich, Robert Hardt, Lilia Colina‐Tenorio, Susanne E. Horvath, Uwe Schulte, Bernd Fakler, Martin van der Laan, Thomas Becker, Rosemary A. Stuart, Nikolaus Pfanner, Heike Rampelt Cell reports 43 (3) : 113772 10.1016/j.celrep.2024.113772 View in FreiDok
• Synaptotagmin-11 facilitates assembly of a presynaptic signaling complex in post-Golgi cargo vesicles Luca Trovo, Stylianos Kouvaros, Jochen Schwenk, Diego Fernández-Fernández, Thorsten Fritzius, Pascal D. Rem, Simon Früh, Martin Gassmann, Bernd Fakler, Josef Bischofberger, Bernhard Bettler EMBO reports 10.1038/s44319-024-00147-0 View in FreiDok

2023

• Activation energy for pore opening in lipid membranes under an electric field Eulalie J. Lafarge, Pierre Muller, André P. Schroder, Ekaterina Zaitseva, Jan C. Behrends, Carlos M. Marques Proceedings of the National Academy of Sciences of the United States of America 120 (11) : e2213112120 10.1073/pnas.2213112120 View in FreiDok
• Mitochondrial complexome reveals quality-control pathways of protein import Uwe Schulte, Fabian den Brave, Alexander Haupt, Arushi Gupta, Jiyao Song, Catrin S. Müller, Jeannine Engelke, Swadha Mishra, Christoph U. Mårtensson, Lars Ellenrieder, Chantal Priesnitz, Sebastian P. Straub, Kim Nguyen Doan, Bogusz Kulawiak, Wolfgang Bildl, Heike Rampelt, Nils Wiedemann, Nikolaus Pfanner, Bernd Fakler, Thomas Becker Nature 614 (7946) : 153-159 10.1038/s41586-022-05641-w View in FreiDok
• Identification of Neurexin-mediated trans-synaptic networks using proteomic and biochemical approaches Spyridon Thivaios, Bernd Fakler, Nikolaus Pfanner, Anne-Kathrin Classen
• Conformational regulation and target-myristoyl switch of calcineurin B homologous protein 3 Florian Becker, Simon Fuchs, Lukas Refisch, Friedel Drepper, Wolfgang Bildl, Uwe Schulte, Shuo Liang, Jonas Immanuel Heinicke, Sierra C. Hansen, Clemens Kreutz, Bettina Warscheid, Bernd Fakler, Evgeny V. Mymrikov, Carola Hunte eLife 12 : e83868 10.7554/elife.83868 View in FreiDok
• Mitochondrial complexome and import network Fabian den Brave, Uwe Schulte, Bernd Fakler, Nikolaus Pfanner, Thomas Becker Trends in cell biology 10.1016/j.tcb.2023.10.004 View in FreiDok
• Synaptic plasticity at the dentate gyrus granule cell to somatostatin-expressing interneuron synapses supports object location memory Gayane Grigoryan, Harumi Harada, Hanna Sophie Knobloch-Bollmann, Antje Kilias, Dorthe Kaufhold, Akos Kulik, Mark D. Eyre, Marlene Bartos Proceedings of the National Academy of Sciences of the United States of America 120 (51) : e2312752120 10.1073/pnas.2312752120 View in FreiDok
• Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes Abhishek Jamwal, Cristina Elena Constantin, Stephan Hirschi, Sebastian Henrich, Wolfgang Bildl, Bernd Fakler, Simon J. Draper, Uwe Schulte, Matthew K Higgins eLife 12 : e83681 10.7554/elife.83681 View in FreiDok
• [Gamma]-2 and GSG1L bind with comparable affinities to the tetrameric GluA1 core Chenlu Yu, Hendrik F. P. Runge, Antara Mukhopadhyay, Gerd Zolles, Maximilian Ulbrich Cellular & molecular biology letters 28 (1) : 54 10.1186/s11658-023-00470-9 View in FreiDok
• AZG1 is a cytokinin transporter that interacts with auxin transporter PIN1 and regulates the root stress response Tomás M. Tessi, Veronica G. Maurino, Mojgan Shahriari, Esther Meissner, Ondřej Novák, Taras Pasternak, Benjamin S. Schumacher, Franck Anicet Ditengou, Zenglin Li, Jasmin Dürr, Noemi S. Flubacher, Moritz Nautscher, Alyssa Williams, Zuzanna Kazimierczak, Miroslav Strnad, Jörg-Oliver Thumfart, Klaus Palme, Marcelo Desimone, William Teale The new phytologist 238 (5) : 1924-1941 10.1111/nph.18879 View in FreiDok
• A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors Sami Boudkkazi, Jochen Schwenk, Naoki Nakaya, Aline Bréchet, Astrid Kollewe, Harumi Harada, Wolfgang Bildl, Akos Kulik, Lijin Dong, Afia Sultana, Gerd Zolles, Uwe Schulte, Stanislav I. Tomarev, Bernd Fakler Neuron 111 (16) : 2544-2556.e9 10.1016/j.neuron.2023.07.013 View in FreiDok
• Soluble amyloid-[beta] precursor peptide does not regulate GABAB receptor activity Pascal Dominic Rem, Vita Sereikaite, Diego Fernández-Fernández, Sebastian Reinartz, Daniel Ulrich, Thorsten Fritzius, Luca Trovo, Salomé Roux, Ziyang Chen, Philippe Rondard, Jean-Philippe Pin, Jochen Schwenk, Bernd Fakler, Martin Gassmann, Tania Rinaldi Barkat, Kristian Strømgaard, Bernhard Bettler eLife 12 : 82082 10.7554/elife.82082 View in FreiDok
• GSG1L-containing AMPA receptor complexes are defined by their spatiotemporal expression, native interactome and allosteric sites Amanda M. Perozzo, Jochen Schwenk, Aichurok Kamalova, Terunaga Nakagawa, Bernd Fakler, Derek Bowie Nature communications 14 : 6799 10.1038/s41467-023-42517-7 View in FreiDok

2022

• A chip-based array for high-resolution fluorescence characterization of free-standing horizontal lipid membranes under voltage clamp Tobias Ensslen, Jan C. Behrends Lab on a chip 22 (15) : 2902-2910 10.1039/d2lc00357k View in FreiDok
• Impact of a single nucleotide polymorphism on the 3D protein structure and ubiquitination activity of E3 ubiquitin ligase arkadia Maria Birkou, Vasilios Raptis, Konstantinos D. Marousis, Athanasios Tsevis, Kyriakos Bourikas, Detlef Bentrop, Vasso Episkopou, Georgios A. Spyroulias Frontiers in molecular biosciences 9 : 844129 10.3389/fmolb.2022.844129 View in FreiDok
• A slit-diaphragm-associated protein network for dynamic control of renal filtration Maciej K. Kocylowski, Hande Aypek, Wolfgang Bildl, Martin Helmstädter, Philipp Trachte, Bernhard Dumoulin, Sina Wittösch, Lukas Kühne, Ute Aukschun, Carolin Teetzen, Oliver Kretz, Botond Gaal, Akos Kulik, Corinne Antignac, Geraldine Mollet, Anna Köttgen, Burulca Göcmen, Jochen Schwenk, Uwe Schulte, Tobias B. Huber, Bernd Fakler, Florian Grahammer Nature communications 13 : 6446 10.1038/s41467-022-33748-1 View in FreiDok
• Resolving isomeric posttranslational modifications using a biological nanopore as a sensor of molecular shape Tobias Ensslen, Kumar Sarthak, Aleksei Aksimentiev, Jan C. Behrends Journal of the American Chemical Society 144 (35) : 16060-16068 10.1021/jacs.2c06211 View in FreiDok
• Circulating multimeric immune complexes contribute to immunopathology in COVID-19 Jakob Ankerhold, Sebastian Giese, Philipp Kolb, Andrea Maul-Pavicic, Reinhard Voll, Nathalie Göppert, Kevin Ciminski, Clemens Kreutz, Achim Lother, Ulrich Salzer, Wolfgang Bildl, Tim Welsink, Nils G. Morgenthaler, Andrea Busse Grawitz, Florian Emmerich, Daniel Steinmann, Daniela Huzly, Martin Schwemmle, Hartmut Hengel, Valeria Falcone Nature communications 13 (1) : 5654 10.1038/s41467-022-32867-z View in FreiDok
• Subunit composition, molecular environment, and activation of native TRPC channels encoded by their interactomes Astrid Kollewe, Yvonne Schwarz, Katharina Oleinikov, Ahsan Raza, Alexander Haupt, Philipp Wartenberg, Amanda Wyatt, Ulrich Boehm, Fabien Ectors, Wolfgang Bildl, Gerd Zolles, Uwe Schulte, Dieter Bruns, Veit Flockerzi, Bernd Fakler Neuron 110 (24) : 4162-4175.e7 10.1016/j.neuron.2022.09.029 View in FreiDok

2021

• Flavonol‐mediated stabilization of PIN efflux complexes regulates polar auxin transport William David Teale, Taras Pasternak, Cristina Dal Bosco, Alexander Dovzhenko, Krystyna Kratzat, Wolfgang Bildl, Manuel Schwörer, Thorsten Falk, Benedetto Ruperti, Jonas V. Schaefer, Mojgan Shahriari, Lena Pilgermayer, Xugang Li, Florian Lübben, Andreas Plückthun, Uwe Schulte, Klaus Palme The EMBO journal 40 (1) : e104416 10.15252/embj.2020104416 View in FreiDok
• Building of AMPA‐type glutamate receptors in the endoplasmic reticulum and its implication for excitatory neurotransmission Jochen Schwenk, Bernd Fakler The journal of physiology / The Physiological Society 599 (10) : 2639-2653 10.1113/jp279025 View in FreiDok
• Electrophysiology on channel-forming proteins in artificial lipid bilayers: next-generation instrumentation for multiple recordings in parallel Ekaterina Zaitseva, Alison Obergrussberger, Conrad Weichbrodt, Mordjane Alissa Boukhet, Frank Bernhard, Christopher Hein, Gerhard Baaken, Niels Fertig, Jan C. Behrends Methods in Molecular Biology 2188 : 67-92 10.1007/978-1-0716-0818-0_4 View in FreiDok
• GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals Pradeep Bhandari, David Vandael, Diego Fernández-Fernández, Thorsten Fritzius, David Kleindienst, Cihan Önal, Jacqueline Montanaro, Martin Gassmann, Peter Jonas, Akos Kulik, Bernhard Bettler, Ryuichi Shigemoto, Peter Koppensteiner eLife 10 : e68274 10.7554/eLife.68274 View in FreiDok
• Discrimination of synthetic polymers with biological nanopores Monasadat Talarimoghari, Jan C. Behrends, Günter Reiter, Marlene Bartos
• The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics Astrid Kollewe, Vladimir Chubanov, Fong Tsuen Tseung, Leonor Correia, Eva Schmidt, Anna Rössig, Susanna Zierler, Alexander Haupt, Catrin Swantje Müller, Wolfgang Bildl, Uwe Schulte, Annette Nicke, Bernd Fakler, Thomas Gudermann eLife 10 : e68544 10.7554/eLife.68544 View in FreiDok
• CEDAR, an online resource for the reporting and exploration of complexome profiling data Joeri van Strien, Alexander Haupt, Uwe Schulte, Hans-Peter Braun, Alfredo Cabrera-Orefice, Jyoti S Choudhary, Felix Evers, Erika Fernandez-Vizarra, Sergio Guerrero-Castillo, Taco W. A. Kooij, Petra Páleníková, Mercedes Pardo, Cristina Ugalde, Ilka Wittig, Lars Wöhlbrand, Ulrich Brandt, Susanne Arnold, Martijn A. Huynen Biochimica et Biophysica Acta. Bioenergetics 1862 (7) : 148411 10.1016/j.bbabio.2021.148411 View in FreiDok

2020

• Electrical recognition of the twenty proteinogenic amino acids using an aerolysin nanopore Hadjer Ouldali, Kumar Sarthak, Tobias Ensslen, Fabien Piguet, Philippe Manivet, Juan Pelta, Jan C. Behrends, Aleksei Aksimentiev, Abdelghani Oukhaled Nature biotechnology 38 (2) : 176-181 10.1038/s41587-019-0345-2 View in FreiDok
• Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network Sam A. Booker, Harumi Harada, Claudio Elgueta, Julia Bank, Marlene Bartos, Akos Kulik, Imre Vida eLife 9 : e51156 10.7554/eLife.51156 View in FreiDok
• Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism Anna J. Khalaj, Fredrik H. Sterky, Alessandra Sclip, Jochen Schwenk, Axel T. Brunger, Bernd Fakler, Thomas C. Südhof Journal of cell biology 219 (9) : e202004164 10.1083/jcb.202004164 View in FreiDok
• The phosphatase PP2A interacts with ArnA and ArnB to regulate the oligomeric state and the stability of the ArnA/B complex Xing Ye, Marian Samuel Vogt, Chris van der Does, Wolfgang Bildl, Uwe Schulte, Lars-Oliver Essen, Sonja Verena Albers Frontiers in microbiology 11 : 1849 10.3389/fmicb.2020.01849 View in FreiDok
• Corrigendum: The phosphatase PP2A interacts with ArnA and ArnB to regulate the oligomeric state and the stability of the ArnA/B complex Xing Ye, Marian Samuel Vogt, Chris van der Does, Wolfgang Bildl, Uwe Schulte, Lars-Oliver Essen, Sonja Verena Albers Frontiers in microbiology 11 : 608420 10.3389/fmicb.2020.608420 View in FreiDok

2019

• Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose Garyfallia I. Makrynitsa, Dioni Ntonti, Konstantinos D. Marousis, Maria Birkou, Minos-Timotheos Matsoukas, Sam Asami, Detlef Bentrop, Nicolas Papageorgiou, Bruno Canard, Bruno Coutard, Georgios A. Spyroulias Journal of structural biology 206 (1) : 119-127 10.1016/j.jsb.2019.02.008 View in FreiDok
• A monoallelic two-hit mechanism in PLCD1 explains the genetic pathogenesis of hereditary trichilemmal cyst formation Steffen Hörer, Slaheddine Marrakchi, Franz P. W. Radner, Gerd Zolles, Lisa Heinz, Thomas O. Eichmann, Cristina Has, Pavel Salavei, Nadia Mahfoudh, Hamida Turki, Andreas D. Zimmer, Judith Fischer Journal of investigative dermatology 139 (10) : 2154-2163.e5 10.1016/j.jid.2019.04.015 View in FreiDok
• Deciphering the nucleotide and RNA binding selectivity of the mayaro virus macro domain Aikaterini C. Tsika, Efstathios Melekis, Sofia-Antigoni Tsatsouli, Nicolas Papageorgiou, Maria J. Maté, Bruno Canard, Bruno Coutard, Detlef Bentrop, Georgios A. Spyroulias Journal of molecular biology 431 (12) : 2283-2297 10.1016/j.jmb.2019.04.013 View in FreiDok
• Activity of the gramicidin A ion channel in a lipid membrane with switchable physical properties Renate Reiter, Ekaterina Zaitseva, Gerhard Baaken, Ibrahim Halimeh, Jan C. Behrends, Andreas Zumbuehl Langmuir 35 (46) : 14959-14966 10.1021/acs.langmuir.9b02752 View in FreiDok
• An ER assembly line of AMPA-receptors controls excitatory neurotransmission and its plasticity Jochen Schwenk, Sami Boudkkazi, Maciej K. Kocylowski, Aline Bréchet, Gerd Zolles, Thorsten Bus, Kaue Costa, Astrid Kollewe, Johannes Jordan, Julia Bank, Wolfgang Bildl, Rolf Sprengel, Akos Kulik, Jochen Roeper, Uwe Schulte, Bernd Fakler Neuron 104 (4) : 680-692.e9 10.1016/j.neuron.2019.08.033 View in FreiDok
• A fully integrated current-mode continuous-time delta-sigma modulator for biological nanopore read-out Mohammad Abdeljaleel Amayreh, Gerhard Baaken, Jan C. Behrends, Yiannos Manoli IEEE transactions on biomedical circuits and systems 13 (1) : 225-236 10.1109/tbcas.2018.2889536 View in FreiDok
• Transgenic short-QT syndrome 1 rabbits mimic the human disease phenotype with QT/action potential duration shortening in the atria and ventricles and increased ventricular tachycardia/ventricular fibrillation inducibility Katja E. Odening, Ilona Bodi, Gerlind Franke, Raphaela Rieke, Anna Ryan de Medeiros, Stefanie Perez Feliz, Hannah Fürniss, Lea Mettke, Konstantin Michaelides, Corinna N. Lang, Johannes Steinfurt, Naga Deepa Pantulu, David Ziupa, Marius Menza, Manfred Zehender, Heiko Bugger, Remi Peyronnet, Jan C. Behrends, Zoltan Doleschall, Axel Zur Hausen, Christoph Bode, Genevieve Jolivet, Michael Brunner European heart journal 40 (10) : 842-853 10.1093/eurheartj/ehy761 View in FreiDok
• Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing Margarita C. Dinamarca, Adi Raveh, Andy Schneider, Thorsten Fritzius, Simon Früh, Pascal D. Rem, Michal Stawarski, Txomin Lalanne, Rostislav Turecek, Myeongjeong Choo, Valérie Besseyrias, Wolfgang Bildl, Detlef Bentrop, Matthias Staufenbiel, Martin Gassmann, Bernd Fakler, Jochen Schwenk, Bernhard Bettler Nature communications 10 (1) : 1331 10.1038/s41467-019-09164-3 View in FreiDok
• Folding unpredicted Jochen Schwenk, Bernd Fakler Science 366 (6470) : 1194-1195 10.1126/science.aaz8642 View in FreiDok
• A pharmacological master key mechanism that unlocks the selectivity filter gate in K+channels Marcus Schewe, Han Sun, Ümit Mert, Alexandra Mackenzie, Ashley C. W. Pike, Friederike Schulz, Cristina Elena Constantin, Kirsty Sophia Vowinkel, Linus J. Conrad, Aytug K. Kiper, Wendy Gonzalez, Marianne Musinszki, Marie Tegtmeier, David C. Pryde, Hassane Belabed, Marc Nazaré, Bert L. de Groot, Niels Decher, Bernd Fakler, Elisabeth P. Carpenter, Stephen J. Tucker, Thomas Baukrowitz Science 363 (6429) : 875-880 10.1126/science.aav0569 View in FreiDok
• High-resolution complexome profiling by cryoslicing BN-MS analysis Catrin Swantje Müller, Wolfgang Bildl, Norbert Klugbauer, Alexander Haupt, Bernd Fakler, Uwe Schulte Journal of visualized experiments (152) : e60096 10.3791/60096 View in FreiDok

2018

• The multifaceted antibacterial mechanisms of the pioneering peptide antibiotics tyrocidine and gramicidin S Michaela Wenzel, Marina Rautenbach, J. Arnold Vosloo, Tjalling Siersma, Christopher H. M. Aisenbrey, Ekaterina Zaitseva, Wikus E. Laubscher, Wilma van Rensburg, Jan C. Behrends, Burkhard Bechinger, Leendert W. Hamoen mBio 9 (5) : e00802-18 10.1128/mBio.00802-18 View in FreiDok
• The GABAB proteome: a differential view on GABAB1a-specific interaction partners Andy Schneider, Bernd Fakler
• Ablation of α2δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo Manuela Nieto-Rostro, Krishma Ramgoolam, Wendy S. Pratt, Akos Kulik, Annette C. Dolphin Proceedings of the National Academy of Sciences of the United States of America 115 (51) : E12043-E12052 10.1073/pnas.1811212115 View in FreiDok
• Munc13-3 is required for the developmental localization of Ca 2+ channels to active zones and the nanopositioning of Ca v 2.1 near release sensors Valentin Kusch, Grit Bornschein, Desirée Loreth, Julia Bank, Johannes Jordan, David Baur, Masahiko Watanabe, Akos Kulik, Manfred Heckmann, Jens-Karl Eilers, Hartmut Schmidt Cell reports 22 (8) : 1965-1973 10.1016/j.celrep.2018.02.010 View in FreiDok

2017

• Neuroplastin and Basigin are essential auxiliary subunits of plasma membrane Ca2+-ATPases and key regulators of Ca2+ clearanceSchmidt N, Kollewe A, Constantin C, Henrich S, Ritzau-Jost A, Bildl W, Saalbach A, Hallermann S, Kulik A, Fakler B, Schulte UNeuron 96: 827-838https://doi.org/10.016/j.neuron.2017.09.038
• Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memoryBröker-Lai J, Kollewe A, Schindeldecker B, Pohle1 J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel MEmbo J 36 (18) : 2770-2789
• A Residue Specific Insight into the Arkadia E3 Ubiquitin Ligase Activity and Conformational PlasticityBirkou M, Chasapis CT, Marousis KD, Loutsidou AK, Bentrop D, Lelli M, Herrmann T, Carthy JM, Episkopou V, Spyroulias GAJ Mol Biol 429 (15) : 2373-2386http://dx.doi.org/10.1016/j.jmb.2017.06.012
• AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual abilityBrechet A, Buchert R, Schwenk J, Boudkkazi S, Zolles G, Siquier-Pernet K, Schaber I, Bildl W, Saadi A, Bole-Feysot C, Nitschke P, Reis A, Sticht H, Al-Sanna’a N, Rolfs A, Kulik A, Schulte U, Colleaux L, Abou Jamra R, Fakler BNat Commun 8: 15910http://dx.doi.org/10.1038/ncomms15910
• Identification of Cav2-PKCβ and Cav2-NOS1 complexes as entities for ultrafast electrochemical coupling.Constantin CE, Müller CS, Leitner MG, Bildl W, Schulte U, Oliver D, Fakler BP Natl Acad Sci Usa 114 (22) : 5707-5712http://dx.doi.org/10.1073/pnas.1616394114
• Ionotropic AMPA-type glutamate and metabotropic GABAB receptors: determining cellular physiology by proteomesBettler B, Fakler BCurr Opin Neurobiol 45: 16-23http://dx.doi.org/10.1016/j.conb.2017.02.011
• Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligandSterky FH, Trotter JH, Lee SJ, Recktenwald CV, Du X, Zhou B, Zhou P, Schwenk J, Fakler B, Südhof TCP Natl Acad Sci Usa 114 (7) : E1253-E1262https://doi.org/10.1073/pnas.1621321114
• KCTD12 auxiliary proteins modulate kinetics of GABA(B) receptor-mediated inhibition in cholecystokinin-containing interneurons.Booker SA, Althof D, Gross A, Loreth D, Müller J, Unger A, Fakler B, Varro A, Watanabe M, Gassmann M, Bettler B, Shigemoto R, Vida I, Kulik ACereb Cortex 27 (3) : 2318-2334

2016

• Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel functionKim G, Luján, R, Schwenk J, Kelly MH, Aguado C, Watanabe M, Fakler B, Maylie J, Adelman JPElife 5:e12637: 1-18http://dx.doi.org/10.7554/eLife.12637
• Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomicsSchwenk J, Pérez-Garci E, Schneider A, Kollewe A, Gauthier-Kemper A, Fritzius T, Raveh A, Dinamarca MC, Hanuschkin A, Bildl W, Klingauf J, Gassmann M, Schulte U, Bettler B, Fakler BNat Neurosci 19 (2) : 233-242http://dx.doi.org/10.1038/nn.4198
• Cryo-slicing Blue Native-Mass Spectrometry (csBN-MS), a Novel Technology for High Resolution Complexome ProfilingMüller CS, Bildl W, Haupt A, Ellenrieder L, Becker T, Hunte C, Fakler B, Schulte UMol Cell Proteomics 15 (2) : 669-681http://dx.doi.org/10.1074/mcp.M115.054080

2015

• NMR study of non-structural proteins--part II: (1)H, (13)C, (15)N backbone and side-chain resonance assignment of macro domain from Venezuelan equine encephalitis virus (VEEV)Makrynitsa GI, Ntonti D, Marousis KD, Tsika AC, Lichière J, Papageorgiou N, Coutard B, Bentrop D, Spyroulias GABiomol Nmr Assign 9 (2) : 247-251
• Inhibitory and excitatory axon terminals share a common nano-architecture of their Cav2.1 (P/Q-type) Ca2+ channelsAlthof D, Baehrens D, Watanabe M, Suzuki N, Fakler B, Kulik AFront Cell Neurosci 9 (315) : 1-11
• NMR study of non-structural proteins-part I: (1)H, (13)C, (15)N backbone and side-chain resonance assignment of macro domain from Mayaro virus (MAYV)Melekis E, Tsika AC, Lichière J, Chasapis CT, Margiolaki I, Papageorgiou N, Coutard B, Bentrop D, Spyroulias GABiomol Nmr Assign 9 (1) : 191-195http://dx.doi.org/10.1007/s12104-014-9572-0
• Backbone and side chain NMR assignment, along with the secondary structure prediction of RRM2 domain of La protein from a lower eukaryote exhibiting identical structural organization with its human homologArgyriou AI, Chasapis CT, Apostolidi M, Konstantinidou P, Stathopoulos C, Bentrop D, Spyroulias GABiomol Nmr Assign 9 (1) : 219-222http://dx.doi.org/10.1007/s12104-014-9578-7

2014

• Soluble cysteine-rich tick salvia proteins Salp15 and Irid-1 from E. coli.Kob P, Vorreiter J, Habicht J, Bentrop D, Wallich R, Nassal MFEBS Open Bio 5: 42-55https://doi.org/10.1016/j.fob.2014.12.002
• More Than a Pore: Ion Channel Signaling ComplexesLee A, Fakler B, Kaczmarek LK, Isom LLJ Neurosci 46 (34) : 15159-15169
• Mutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channelsSubramaniam M, Althof D, Gispert S, Schwenk J, Auburger G, Kulik A, Fakler B, Roeper JJ Neurosci 34 (41) : 13586-13599http://dx.doi.org/10.1523/JNEUROSCI.5069-13.2014
• Regional Diversity and Developmental Dynamics of the AMPA-Receptor Proteome in the Mammalian BrainSchwenk J, Baehrens D, Haupt A, Bildl W, Boudkkazi S, Röper J, Fakler B, Schulte UNeuron 84 (1) : 41-54http://dx.doi.org/10.1016/j.neuron.2014.08.044
• NMR conformational properties of an Anthrax Lethal Factor domain studied by multiple amino acid-selective labelingVourtsis DJ, Chasapis CT, Pairas G, Bentrop D, Spyroulias GABiochem Bioph Res Co 450 (1) : 335-340https://doi.org/10.1016/j.bbrc.2014.05.123
• Auxiliary GABAB Receptor Subunits Uncouple G Protein βγ Subunits from Effector Channels to Induce DesensitizationTurecek R, Schwenk J, Fritzius T, Ivan kova K, Zolles G, Adelfinger L, Jacquier V, Besseryrias V, Gassmann M, Schulte U, Fakler B, Bettler BNeuron 82 (5) : 1032-1044http://dx.doi.org/10.1016/j.neuron.2014.04.015
• Cornichon2 Dictates the Time Course of Excitatory Transmission at Individual Hippocampal SynapsesBoudkkazi S, Brechet A, Schwenk J, Fakler BNeuron 82 (4) : 848-858http://dx.doi.org/10.1016/j.neuron.2014.03.031
• (1)H, (15)N, (13)C assignment and secondary structure determination of two domains of La protein from D. discoideum.Apostolidi M, Vourtsis DJ, Chasapis CT, Stathopoulos C, Bentrop D, Spyroulias GABiomol Nmr Assign 8 (1) : 47-51http://dx.doi.org/10.1007/s12104-012-9450-6

2013

• Up-regulation of GABA(B) Receptor Signaling by Constitutive Assembly with the K+ Channel Tetramerization Domain-containing Protein 12 (KCTD12).Ivanovka K, Tureccek R, Fritzius T, Seddik R, Prezeau L, Comps-Agrara L, Pin JP, Fakler B, Besseyrias V, Gassmann M, Bettler BJ Biol Chem 288 (34) : 24848-24856http://dx.doi.org/10.1074/jbc.M113.476770
• Otoferlin Couples to Clathrin-Mediated Endocytosis in Mature Cochlear Inner Hair CellsDuncker SV, Franz C, Kuhn S, Schulte U, Campanelli D, Brandt N, Hirt B, Fakler B, Blin N, Ruth P, Engel J, Marcotti W, Zimemrmann U, Knipper MJ Neurosci 33 (22) : 9508-9519
• Ligand-Gating by Ca2+ Is Rate Limiting for Physiological Operation of BKca ChannelsBerkefeld H, Fakler BJournal of Neuroscience 33 (17) : 7358-7367http://dx.doi.org/10.1523/JNEUROSCI.5443-12.2013

2012

• Opposite Effects of KCTD Subunit Domains on GABAB Receptor-mediated DesensitizationRiad Seddik, Jungblut Stefan P, Silander OK, Rajalu M, Fritzius t, Besseyrias V, Jacquier, Fakler B, Gassmann M, Bettler BJOURNAL OF BIOLOGICAL CHEMISTRY 287 (4) : 39869-39877http://dx.doi.org/10.1074/jbc.M112.412767
• High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor ComplexesSchwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Müller C, Bildl W, Baehrens D, Hüber B, Kulik A, Klöcker N, Schulte U, Fakler BNeuron 74 (4) : 621-633http://dx.doi.org/10.1016/j.neuron.2012.03.034
• AMPA receptors commandeer an ancient cargo exporter for use as an auxiliary subunit for signalingHarmel N, Cokic B, Zolles G, Berkefeld H, Maruic V, Fakler B, Stein V, Klöcker NPlos One 7 (1) : e30681http://dx.doi.org/10.1371/journal.pone.0030681
• NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligaseChasapis CT, Kandias NG, Episkopou V, Bentrop D, Spyroulias GAProteins 80 (5) : 1484-1489http://dx.doi.org/10.1002/prot.24048
• Extending The Dynamic Range Of Label-Free Mass Spectrometric Quantification Of Affinity PurificationsBildl W *, Haupt A *, Müller CS *, Biniossek M, Thumfart JO, Hüber B, Fakler B, Schulte UMol Cell Proteomics 11 (2) : 007955-1-007955-12http://dx.doi.org/10.1074/mcp.M111.007955

2011

• Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autismLòpez-Hernández T, Ridder MC, Montolio M, Capdevila-Nortes X, Polder E, Sirisi S, Duarri A, Schulte U, Fakler B, Nunes V, Scheper GC, Martinez A, Estévez R, van der Knaap MSAm J Hum Genet 88 (4) : 422-432http://dx.doi.org/10.1016/j.ajhg.2011.02.009
• Unravelling the Conformational Plasticity of the Extracellular Domain of a Prokaryotic nAChR Homologue in Solution by NMRChasapis CT, Argyriou AL, Corringer PJ, Bentrop D, Spyroulias GABiochemistry-us 50 (45) : 9681-9683
• A Synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricitySchaechinger TJ, Gorbunov D, Halaszovich CR, Moser T, Kügler S, Fakler B, Oliver DEmbo J 30: 2793-3804
• Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b and 16 in the mouse brainMetz M, Gassmann M, Fakler B, Schaeren-Wiemers N, Bettler BJ Comp Neurol 519 (8) : 1435-1454
• Ion channels and their molecular environments glimpses and insights from functional proteonmicsSchulte U, Müller C, Fakler BSemin Cell Dev Biol 22 (2) : 132-144http://dx.doi.org/10.1016/j.semcdb.2010.09.015

2010

• Conformational Dynamics of the Anthrax Lethal Factor Catalytic Center.Dalkas GA, Chasapis CT, Gkazonis PV, Bentrop D, Spyroulias GABiochemistry-us 49 (51) : 10767-10769
• Gene expression associated with the onset of hearing detected by differential display in ratorgan of cortReisinger E, Meintrup D, Oliver D, Fakler BEur J Hum Genet 18 (12) : 1327-1332
• Ca2+-activated k+ channels: from protein complexes to functionBerkefeld H, Fakler B, Schulte UPhysiol Rev 90 (4) : 1437-1459
• Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brainMüller C, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte UP Natl Acad Sci Usa 107 (34) : 14950-14957
• Purification and biophysical characterization of the core protease domain of anthrax lethal factor.Gzonis PV, Dalkas GA, Chasapis CT, Vlamis-Gardikas A, Bentrop D, Spyroulias GABiochem Bioph Res Co 396 (3) : 643-647
• Native GAB(B) receptors are heteromultimers with a family of auxiliary subunitsSchwenk J, Metz M, Zolles G, turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K, Seddik R, Tiao JY, Rajalu M, Trojanova J, Rohde V, Gassmann M, Schuklte U, Fakler B, Bettler BNature 465: 231-235

2009

• Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulationZolles G, Wenzel D, Bildl W, Schulte U, Hofmann A, Müller CS, Thumfart J, Vlachos a, Deller T, Pfeifer A, Fleischmann BK, Roeper J, Fakler B, Klöcker NNeuron 62 (6) : 814-825
• High yield expression and NMR characterization of Arkadia E3 ubiquitin ligase RiNG-H2 finger domainKandias NG, Chasapis CT, Bentrop D, Episkopou V, Spyroulias GABiochemical and Biophysical Research Communications 378 (3) : 498-502
• Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptorsSchwenk J, Harmel N, Zolles G, Bildl W, Kulik A, Heimrich B, Chisaka O, Jonas P, Schulte U, Fakler B, Klöcker NScience 323: 1313-1319

2008

• Control of K(Ca) channels by calcium nano/microdomainsFakler B, Adelman JPNeuron 59 (6) : 873-881
• Repolarizing responses of BKca-Cav complexes are distinctly shaped by their cav subunitsBerkefeld H, Fakler BJ Neurosci 28 (33) : 8238-8245
• Recycling endosomes supply cardiac pacemaker channels for regulated surface expressionHardel N, Harmel N, Zolles G, Fakler B, Klöcker NCardiovasc Res 79 (1) : 52-60
• NMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexesSchwenk J, Zolles G, Kandias NG, Neubauer I, Kalbacher H, Covarrubias M, Fakler B, Bentrop DJ Biol Chem 283 (27) : 18937-18946

2007

• Organization and regulation of small conductance Ca2+-activated K+ channel multiprotein.Allen D, Fakler B, Maylie J, Adelman JPJ Neurosci 27 (9) : 2369-2376

2006

• Pacemaking by HCN chnallens requires interaction with phosphoinositidesZolles G, Klöcker N, Wenzel D, Weisser-Thomas J, Fleischmann BK, Roeper J, Fakler BNeuron 52: 1027-1036
• Interaction of Prestin (SLC26A5) with monovalent intracellular anionsOliver D, Schächinger T, Fakler BNovartis Found Symp. 273: 244-253
• BKca-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signalingBerkefeld H, Sailer CA, Bildl W, Rohde V, Thumfart JO, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus HG, Schulte U, Fakler BScience 314 (5799) : 615-620
• The role of BKca channels in electrical signal encoding in the mammalian auditory peripheryOliver D, Taberner AM, Thurm H, Sausbier M, Arntz C, Ruth P, Fakler B, Liberman MCJournal of Neuroscience 26 (23) : 6181-6189
• The epilepsy linked lgi1 protein assembles into presynaptic kv1 Channels and inhibits inactivation by kvbeta1 Neuron 49Schulte U, Thumfart JO, Klöcker N, Sailer CA, Bildl W, Biniossek M, Dehn D, Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler BNeuron 49 (5) : 697-706